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How to create and manipulate (read/write) Excel (XLSX) documents with complex rules using general programming languages?

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Our organization (blindness non-profit in California) is obligated to submit reports to grant organizations (e.g., Department of Rehabilitation) on a regular basis. Most of the time, this means exporting data from our case management system and copying it manually into an Excel template file containing several worksheets provided by the grant organizations. Data validation rules, summaries, etc. are all implemented with Excel functions; basically, the Excel files are treated as databases (I know, blasphemy).

I'm looking for projects written in general programming languages (so VBA is not an option) to automate this process of filling out the reports - or, when the provided Excel templates are protected and the org is not willing to accommodate this use case, to re-create them from scratch with the existing functionality.

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What about Python+`xlwings`? (2 comments)

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All of these projects use Microsoft's OpenXML SDK for Office behind the scenes:

1. .NET (F#, C#)

The F# Guide recommends NPOI, which also seems to be the most popular and most up-to-date, but there are others as well (ClosedXML, EPPlus).

2. Elixir

3. Python

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