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This won't work for every use-case, but for mine I was able to use the [`G_TEST_OPTION_ISOLATE_DIRS` flag](https://docs.gtk.org/glib/const.TEST_OPTION_ISOLATE_DIRS.html) for [`g_test_init ()`](https://docs.gtk.org/glib/func.test_init.html) like so:

```c
g_test_init (&argc, &argv, G_TEST_OPTION_ISOLATE_DIRS, NULL);
```

This only affects XDG directories, so if your program doesn't respect those or operates outside of them this will do nothing. But for my use-case this is perfect.